Hand, foot, and mouth disease is caused by enterovirus infection, with symptoms including oral pain, blisters on the hands, feet, and mouth, loss of appetite, and a lack of energy. These symptoms are often accompanied by a fever that can last for several days. Once diagnosed with hand, foot, and mouth disease, it is important to isolate to prevent cross-infection. Antiviral medications and oral mucosal sprays can be used to assist in the recovery of the oral mucosa.